Solving COVID
November 17, 2020

Regular, over-the-counter mouthwashes have shown "promising signs" of killing the COVID-19 coronavirus in saliva, scientists at Cardiff University in Wales have found.

The study discovered that mouthwashes containing at least 0.07 percent cetylpyridinium chloride destroyed the virus within 30 seconds of being exposed to it in a lab. The report hasn't been peer reviewed, and the next step is to see if mouthwashes are as effective as they are in patients as they were in the lab setting. Results from a clinical trial at the University Hospital of Wales are expected next year.

While the news is encouraging, it seems likely mouthwashing would be an addition to preventative measures like hand washing, social distancing, and mask-wearing, as opposed to a treatment since the liquid would not be able to reach the respiratory tract or the lungs, BBC News notes.

The results come after another study also found CPC-based mouthwashes to be effective in reducing viral load, reports BBC. Read more at BBC News and take a look at the study's findings here. Tim O'Donnell

November 23, 2020

The coronavirus almost certainly originated in another species before jumping to humans (perhaps infecting a third party species in between), but new research is suggesting that humans could also play the role of vector, National Geographic reports.

A new study led by Harris Lewin, a professor of ecology and evolution at University of California, Davis, found that humans could potentially spread the virus to wild animals, and they probably already have among animals in captivity. For example, Lewin said it's likely lions and tigers that contracted the virus at the Bronx Zoo in New York were infected by human zookeepers.

That could put endangered species — especially close human relatives like the western lowland gorilla, the Sumatran orangutan, chimpanzees, and bonobos — at high risk of a COVID-19 outbreak, especially in places where wild animals are more likely to come into close contact with humans, Lewin told Nat Geo.

Lewin's co-author Klaus-Peter Koepfli singled out Africa's eastern gorilla as another high-risk species because the fewer than 5,000 remaining individuals live in close-knit family groups, making them more vulnerable to their own pandemic.

The good news is there's no evidence the virus is spreading among wild animal populations, and the animals that have been infected in experimental settings have mostly exhibited mild cases. But the risk remains, so Koepfli and Lewin are calling for a focus on preventative methods such as national park staffers getting regularly tested to mitigate the threat. Read more at National Geographic. Tim O'Donnell

November 23, 2020

An interim trial analysis for Oxford-AstraZeneca's COVID-19 vaccine found the candidate's average efficacy to be 70 percent. While considered encouraging, it falls short of the rates shown by Pfizer/BioNTech and Moderna, whose vaccines appear to be more than 90 percent effective.

Still, the Oxford-AstraZeneca candidate has a few key advantages — it can be stored at regular refrigerators temperatures for a long period of time, and it's much cheaper than the other candidates, which means it could be particularly crucial for developing nations and rural communities around the world.

The vaccine costs just $3 to $4 per dose. In comparison, the Pfizer and Moderna candidates cost around $20 and $30, respectively. AstraZeneca has also made a "no-profit" pledge, and the more-established technology used by Oxford means it will be easier to mass produce cheaply, BBC News notes. Read more at BBC and The Financial Times. Tim O'Donnell

November 23, 2020

Oxford University and drugmaker AstraZeneca announced Monday morning that their COVID-19 vaccine candidate had proved to be 70 percent effective in its Phase Three trial of 20,000 volunteers in Britain and Brazil. And Oxford Vaccine Group director Andrew Pollard told BBC Radio 4 Today that the vaccine appeared to be 90 percent effective when people were given a half-dose of the vaccine followed by a full dose.

"We are really pleased with these results," Pollard said. "What we have got is a vaccine that is able to protect against coronavirus disease and, importantly, there were no hospitalizations or severe cases in anyone who had the Oxford vaccine." Sarah Gilbert, the vaccine's architect, said "the announcement today takes us another step closer to the time when we can use vaccines to bring an end to the devastation caused by" the new coronavirus.

Britain has ordered 100 million doses of the Oxford vaccine, and if U.K. regulators approve it for emergency use, the country is ready to roll out an aggressive immunization program. Residents and staff of nursing homes are first on the list of those approved for vaccinations, followed by health care workers and people over 85, then consecutively lower age groups.

"After Pfizer and Modena both produced vaccines delivering 95 percent protection from COVID-19, a figure of 70 percent is relatively disappointing," BBC News reports. "However, anything above 50 percent would have been considered a triumph just a month ago. This vaccine can also be stored at fridge temperature, which means it can be distributed to every corner of the world, unlike the Pfizer/BioNTech and Moderna vaccines, which need to be stored at much colder temperatures." Peter Weber

November 22, 2020

Pfizer's coronavirus vaccine, which was submitted to the Food and Drug Administration for an emergency use authorization this week and could be rolled out by mid-December, must be kept in ultra-cold conditions and will initially be shipped in boxes that hold a minimum of 975 doses. Once a vial is thawed and diluted to make five shots, people receiving the vaccine (early on that is expected to be health-care workers), will then have just six hours to get inoculated, Politico reports. Whatever is left over will then spoil.

While there's great excitement about the vaccine's pending authorization, the concern about wasted shots is very real, "especially early on when it will be practically liquid gold," Douglas Hoey, CEO of the National Pharmacists Association, told Politico.

States are trying to come up with ways to mitigate the risk, but spoiled doses are inevitable. Maryland health officials told the Centers for Disease Control and Prevention that as much as 5 percent of the vaccine the state is allocated could go unused in the initial rollout, especially because rural counties may not be able to use up all 975 doses on their own. To counter, Maryland is considering creating regional clinics where people in high priority groups from different rural communities could come to get vaccinated.

Oregon is considering contracting emergency medical providers to drive around and divy up the vaccine among remote areas, Politico reports. And North Dakota wants to repackage the vaccine into smaller boxes — Pfizer says it's working on a smaller pack size that won't be ready until next year — while also identifying people in the next priority group to get a shot if there are any doses left over.

Regardless, the situation will be tricky, but Moderna's vaccine, which will also soon be up for FDA authorization, is expected to be a bit easier to distribute than Pfizer's. Read more at Politico. Tim O'Donnell

November 22, 2020

The Food and Drug Administration on Saturday issued an emergency use authorization for Regeneron's antibody cocktail, a treatment that was given to President Trump in October after he tested positive for COVID-19. Trump credited the cocktail for aiding his recovery.

For now, the authorization applies only to high-risk patients — people over the age of 65 or those who have underlying conditions — and the treatment is meant to be administered in the early stages of an infection; it has not been authorized for patients hospitalized with COVID-19 or those who require oxygen therapy.

Demand is likely to outpace supply with infections rising rapidly across the U.S., but Regeneron said it hopes to have enough doses for 80,000 patients by the end of November, 200,000 by the first week in January, and 300,000 by the end of January.

The cocktail consists of two monoclonal antibodies that target the spike protein the coronavirus uses to enter cells. A similar therapy developed by Eli Lilly was granted an emergency use by the FDA earlier this month. Read more at Bloomberg and CNN. Tim O'Donnell

November 20, 2020

Pfizer said Friday it's submitting its application to the Food and Drug Administration for emergency use authorization of its COVID-19 vaccine. If the FDA and its independent scientific advisers decide the vaccine is safe and effective after a public meeting in early December, the first shots could go out to groups of Americans, apportioned according to criteria to be determined by a separate government advisory group. Pfizer said that it may have 25 million doses of vaccine ready in December, 30 million more in January, and another 35 million doses in February and March. People will need two doses of the vaccine.

Pfizer and its German partner BioNTech announced earlier this week that its vaccine had proved safe and 95 percent effective in its large, ongoing human trial. The FDA and its advisory board will conduct their own analysis of Pfizer's data, and emergency use authorization means the FDA will continue to monitor the vaccine. Pfizer said it has also started applications for approval in Britain and Europe. Moderna, whose vaccine also showed 95 percent efficacy in human trials, is expected to submit its FDA emergency use application in the next week or two.

"Help is on the way," Dr. Anthony Fauci, the top U.S. infectious disease expert, said Thursday, adding that in the meantime, "we need to actually double down on the public health measures as we're waiting for that help to come." If the vaccines win approval and can be efficiently distributed to Americans willing to be inoculated, the pandemic could be effectively under control by mid-spring or summer. Peter Weber

November 19, 2020

The benefits of cracking down early and hard against COVID-19 are becoming even more clear.

Early in the coronavirus pandemic, some states — mainly those in the northeast experiencing early case surges — decided to implement tough lockdown measures and mask mandates to control their spreads. And on the whole, they're avoiding recent major outbreaks seen in states that didn't take as much action, a New York Times analysis of Oxford's COVID-19 government response tracker shows.

New York saw one of the earliest and worst spikes in COVID-19 cases back in the spring, and implemented lockdowns, mandatory quarantines, and other measures to stop the spread. It curbed its outbreak before the summer, and while cases are on the rise again, New York is shutting down schools and businesses as positivity rates remain in the single digits.

In contrast, many Midwestern states implemented barely any containment measures throughout the spring and summer — North Dakota and Iowa only just implemented a mask mandate a few days ago, and South Dakota still hasn't. As of Nov. 16, North Dakota has seen an average of 175 coronavirus cases per 100,000 people in the state, while South Dakota has seen about 65 people hospitalized for every 100,000.

Compare every state's coronavirus measures with its case counts and hospitalizations at The New York Times. Kathryn Krawczyk

November 19, 2020

Early-stage trials indicated that British drug maker AstraZeneca's coronavirus vaccine, which it is developing with the University of Oxford, was safe and effective, according to results published Thursday in The Lancet, a top medical journal. The study of 560 healthy adults found that the vaccine produced a similar immune response in all adults, meaning it could protect older people who face a "significant risk" of developing a severe illness if they are infected with the coronavirus.

"We hope that this means our vaccine will help to protect some of the most vulnerable people in society," said Dr. Maheshi Ramasamy, a co-author of the study at the University of Oxford, "but further research will be needed before we can be sure." Harold Maass

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